Endocrine Abstracts

In our country, as in others, there is a lack of data on the success rate of transsphenoidal surgery for producing pituitary adenomas. We evaluated the results reported in TESSPAIN, a retrospective multicenter nationwide project that includes all the TSS performed in the participating centers in the period between 2018 and 2022, both included. Surgical treatment success is defined according to the published criteria for each disease: normal IGF-1 and GH after 75 g of oral gluc...

Introduction: Few studies to date have attempted to evaluate the early efficacy of first-generation somatostatin analogs in somatotroph macroadenomas.Objective: To investigate the short-term efficacy of primary therapy with lanreotide 120 mg on tumor shrinkage and ophthalmologic symptoms in newly diagnosed patients with acromegaly.Design and patients: This single-center retrospective study included 21 patients who were newly diagno...

CNB is increasingly being used as a diagnostic test for thyroid nodules with an inadequate (Bethesda 1) or indeterminate (Bethesda 3 and 4) FNAC results, which can account for up to 30% of the samples in some studies. CNB, using larger specimens and histological sections rather than cytological samples, allows better definition. We propose a simplified four-tiered classification of CNB specimens instead of the Bethesda system and evaluate its efficiency compared to definitive ...

Introduction: Current guidelines propose temozolomide (TMZ) as the first-line chemotherapy for aggressive pituitary neuroendocrine tumors (PitNETs), but no clinical trials have been conducted and clinical experience in this context is limited.Patients and methods: A retrospective study of patients with aggressive pitNETs treated with TMZ was conducted by the members of the Neuroendocrinology Working Area of the Spanish Society of Endocrinology and Nutrit...

Background: Conventional therapy for chronic hypoparathyroidism (cHP) is often unable to maintain stable normal serum calcium (Ca) levels for a full 24 h, to control symptoms, to prevent the detrimental long-term effects on the kidney and to preserve normal bone architecture. Eneboparatide (AZP-3601) is a novel 36-amino-acid peptide specifically designed to activate the R0 conformation of the PTH receptor 1, that results in a prolonged calcemic response and a sustai...

Background: Conventional therapy with oral calcium (Ca) and active vitamin D (vitD) supplementation for chronic hypoparathyroidism (cHP) can induce or aggravate hypercalciuria and may lead to detrimental long-term renal complications. Eneboparatide (AZP-3601) is a novel 36-amino-acid peptide with a short half-life designed to activate the R0 conformation of the PTH 1 receptor which produces a prolonged calcemic response. This phase 2a study examined the effects of e...

Intracranial tumors (IT) comprise a heterogenous group of neoplasias (e.g., pituitary/brain tumors and craniopharyngiomas), characterized by difficult diagnosis based on MRI, challenging prognostic predictors and lack of effective therapeutic strategies. In addition, these tumors are usually associated with neurological disorders and severe comorbidities (e.g., those associated with Cushing syndrome, Acromegaly, etc.), worsening the quality life of patients. In this context, s...

Methods: Descriptive retrospective study of the clinical outcomes and RNA expression in aggressive pituitary tumors treated with temozolomide. RNA expression was studied in tumor samples normalized to housekeeping genes including GH, POMC, PRL, αsub, FSH, LH, TSH, sst1, sst2, sst3, sst5, sst5b, sst5c, DR1, DR2T, DR2L, DR4, DR5, Ghrelin, In1-Ghrelin, GOAT, GHRR1b, AVPR1b, GHRH-R, GnRH-R, Ki-67, PTTG1, CRHR1.Results: Ten patients were treated. 30% (3)...

Introduction: Minimally invasive surgery has become the standard surgical procedure in Primary Hyperparathyroidism (PHP). Targeted parathyroidectomy is associated with a shorter operative duration, a lower risk of complications and a greater patient satisfaction. This approach is dependent on precise localization of the abnormal gland. 99mTc-sestamibi scintigraphy and ultrasonography are acceptable imaging modalities to detect parathyroid adenoma prior to operation but discrep...

Introduction: Diabetes mellitus secondary to exocrine pancreas diseases (pancreatogenic DM) has an unknown incidence and is considered underdiagnosed. Our objective was to evaluate the glycemic control parameters in patients with pancreatogenic DM who started Flash glucose monitoring (FGM).Methods: Prospective, observational study in a Spanish hospital. Patients with pancreatogenic DM who started FGM from January 2021 to August 2022 were recruited. Patie...